Should you get your genome sequenced? For a growing number of people, the answer is an emphatic yes. Genomic sequencing can reveal hereditary cancer risks, cardiac conditions, pharmacogenomic variants that affect drug response, carrier status for reproductive planning, and rare disease diagnoses that have eluded conventional testing. The cost has fallen below $200. The question has shifted from 'can I afford to get sequenced?' to 'can I afford not to?'